Single-cell analysis and spatial resolution of the gut microbiome Over the past decade it has become clear that various aspects of host physiology, metabolism, and immunity are intimately associated with…
Serotonin reduction in post-acute sequelae of viral infection Post-acute sequelae of COVID-19 (PASC, “Long COVID”) pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have…
A subpopulation of lipogenic brown adipocytes drives thermogenic memory Sustained responses to transient environmental stimuli are important for survival. The mechanisms underlying long-term adaptations to temporary shifts in abiotic factors…
Hierarchical contribution of individual lifestyle factors and their interactions on adenomatous and serrated polyp risk Background: Individual colorectal polyp risk factors are well characterized; however, insights into their pathway-specific interactions…
The enteric nervous system relays psychological stress to intestinal inflammation Mental health profoundly impacts inflammatory responses in the body. This is particularly apparent in inflammatory bowel disease (IBD), in which…
Preterm birth is associated with xenobiotics and predicted by the vaginal metabolome Spontaneous preterm birth (sPTB) is a leading cause of maternal and neonatal morbidity and mortality, yet its prevention…