Weak Microbial Metabolites: a Treasure Trove for Using Biomimicry to Discover and Optimize Drugs For decades, traditional drug discovery has used natural product and synthetic chemistry approaches to generate libraries…

The bidirectional nature of microbiome-epithelial cell interactions The biogeography of the mammalian intestine is remarkable in that a vast microbial consortium exists inside the organism, surrounded by intestinal epithelial cells.…

High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function Background & aims: The intestinal barrier protects intestinal cells from microbes and antigens in the lumen-breaches can alter the…

Small molecules, big effects: microbial metabolites in intestinal immunity The mammalian intestine is host to a vast number of microbial organisms. The immune system must balance tolerance with innate and…

The biogeography of colonization resistance Antibiotic overuse has led to a rise of multidrug-resistant pathogens and increased morbidity. A new study shows that the microbiome can prime two different host…